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Teratogen

Definition

A teratogen is an agent that can cause malformations of an embryo or fetus. This can be a chemical substance, a virus or ionizing radiation.

This is closely related to a fetotoxin, an agent that causes poisoning effects on a developing fetus.

Both fetotoxins and teratogens are reproductive toxins, substances which cause damage to one's reproductive and/or endocrine system and/or a developing fetus.

Additional Info

Pregnant women should avoid all contact with teratogens, particularly during the first three months of pregnancy, as this can result in damage to the developing child. For example, alcohol is a teratogen and drinking during pregnancy can lead to a child born with fetal alcohol syndrome.

Many drugs can also have an adverse effect on developing fetuses, the most infamous example being thalidomide. This drug was used to control morning sickness, but was withdrawn from the market after it was discovered to cause limb and other developmental deformities.

There are few examples of transplacental carcinogens, substances which can cause fetuses exposed during pregnancy to eventually develop cancer. The best-known example is DES, diethylstilbestrol, a compound formerly used to prevent miscarriages before its trans-generational carcinogenic activity was known.

MSDS Relevance

Always minimize the use and release of teratogens (or believed teratogens) in the workplace. Women who are of child-bearing age should pay particular attention to teratogenic materials because they could be pregnant without knowing it and expose their fetus. Teratogens typically cause their most severe damage during the first 3 months of pregnancy when many pregnancies are not yet known. Many teratogens cause effects at very low exposure levels.

Further Reading

• The National Toxicology Program's Center for the Evaluation of Risks to Human Reproduction (CERHR).
• OSHA's page on reproductive hazards with additional resources, evaluation, controls, standards and more.
• OSHA Chemical Sampling Information lists the known health effects of a number of chemicals.
• The March of Dimes seeks to reduce birth defects and infant mortality.
• The American College of Environmental Medicine has great info on teratogens that includes a list of known teratogens.

See also: clastogen, mutagen, carcinogen.

Disclaimer: The information contained herein is believed to be true and accurate, however ILPI makes no guarantees concerning the veracity of any statement. Use of any information on this page is at the reader's own risk. ILPI strongly encourages the reader to consult the appropriate local, state and federal agencies concerning the matters discussed herein.